Chemical Properties of Sodium Hyaluronate

Sodium hyaluronate is composed of repeating units of glucuronic acid and N-acetylglucosamine connected via glycosidic bonds. Structurally, it is a linear polysaccharide with a molecular weight ranging from 10,000 to 10,000,000 Da, depending on its source and application. The molecule is hydrophilic due to its numerous hydroxyl groups, which contribute to its exceptional water-binding capacity—up to 1000 times its own weight in water. This property is critical for its biological functions, such as maintaining tissue hydration and elasticity. Depending on the molecular weight, it can be roughly divided into four categories: oligo, small molecular, medium molecular (regular), and high molecular. Its powder form is soluble in water, forming a transparent solution commonly found in concentrations of 1% and 0.5% in the market.

Methods of Production

The synthesis of sodium hyaluronate can be achieved through bacterial fermentation or enzymatic processes. Bacterial fermentation involves cultivating specific strains of Streptococcus zooepidemicus or genetically engineered bacteria capable of producing high yields of hyaluronic acid. Enzymatic methods utilize enzymes like hyaluronate synthase to catalyze the polymerization of glucuronic acid and N-acetylglucosamine. Our production of sodium hyaluronate utilizes biological fermentation, a well-established method known for its efficiency and scalability. This process involves cultivating specific strains of bacteria under controlled conditions. And these bacteria are adept at synthesizing hyaluronic acid through enzymatic processes, yielding high-purity sodium hyaluronate. This method is favored for its ability to produce consistent quality and quantity of the product, making it suitable for diverse applications in pharmaceuticals, cosmetics, and healthcare.

Usage of Sodium Hyaluronate in Supplements

Sodium hyaluronate is commonly used in dietary supplements, particularly those focused on joint health and skincare. When taken orally, sodium hyaluronate is believed to be absorbed by the body and distributed to tissues where it can exert its effects. In joints, it helps to maintain synovial fluid viscosity and cushioning, which supports joint function. For skincare, it contributes to moisture retention in the skin, helping to improve hydration levels and reduce the appearance of fine lines and wrinkles.

Joint Health: Sodium hyaluronate is widely used in supplements aimed at supporting joint health. It is believed to help lubricate joints and improve their flexibility and mobility. This makes it a popular ingredient in formulations targeting conditions like osteoarthritis, where joint lubrication is crucial for reducing friction and discomfort.

Skincare: In addition to its role in topical skincare products, sodium hyaluronate is also used orally in supplements targeting skin health. When ingested, it is thought to hydrate the skin from within by attracting and retaining moisture, helping to maintain skin elasticity and smoothness.

Eye Health: Some supplements include sodium hyaluronate for its potential benefits in eye health. It can contribute to eye lubrication and may be used in formulations aimed at alleviating dry eye symptoms or supporting overall eye comfort.

Market Trends and Future Outlook

The market for sodium hyaluronate supplements is expanding, driven by aging populations seeking joint support and a growing interest in holistic skincare solutions. Manufacturers are innovating with formulations that combine sodium hyaluronate with other ingredients known to support joint health or enhance skin benefits.