NMN

• Purity of more than 99.5%      

  Innovative process with enzymic method for high efficiency conversion and green safe products.

• High bioavailability                   

  Microencapsulation preparation technology is used for effective protection of biological activity and quick adjustment and promotion of absorption.

• Good stability at room temperature

  Stable properties at ambient temperature, easy for storage and use by customers.

• Density and formulation customization available

  Fully satisfying the application requirements of different products, such as tablets, capsules, etc.

Mechanism of NMN

NMN (β-Nicotinamide mononucleotide) functions in the human body by converting into NAD. NAD+ (cozymase I), an important coenzyme in the human body, exists in all the living cells and plays a vital role in regulating cell senescence and maintaining normal functions of the body.

What's the function of NMN?

Support NAD+producing

Activate SIRTUINS

Repair DNA damage

Help with weight management

Promote brain health

Improve insulin sensitivity

Promote the regeneration of blood vessels, maintain the elasticity of blood vessels and enhance their endurance and vitality.

Prevent the decline of bone density and improve vision and immune functions.

Support metabolism to promote energy production.

Key Benefits of NMN:

1. Anti-Aging: NMN is linked to slowing the aging process by boosting NAD+ levels, which can help improve energy metabolism, DNA repair, and reduce the signs of aging.

2. Improved Cellular Energy: NAD+ is crucial for converting nutrients into energy, helping to maintain cellular function and vitality.

3. Cognitive Support: Enhances brain function by supporting mitochondrial health and energy in neurons.

4. Metabolic Health: May improve insulin sensitivity, promote healthy metabolism, and support weight management.

5. Cardiovascular Health: May enhance blood flow and overall heart function.

How is NMN Synthesized In the Body?

NMN is produced from B vitamins in the body. The enzyme responsible for making NMN in the body is called nicotinamide phosphoribosyltransferase (NAMPT).  NAMPT attaches  nicotinamide (a vitamin B3) to a sugar phosphate called PRPP (5’-phosphoribosyl-1-pyrophosphate). NMN can also be made from ‘nicotinamide riboside’ (NR) through the addition of a phosphate group.

‘NAMPT’ is the rate-limiting enzyme in the production of NAD+. This means lower levels of NAMPT cause decreased NMN production, resulting in decreased NAD+ levels. Adding precursor molecules like NMN can also speed up NAD+ production.

How are NMN Supplements Absorbed and Distributed Throughout the Body?

NMN appears to be absorbed into cells through a molecular transporter embedded in the cell surface. Being smaller than NAD+, the NMN molecule may be absorbed more efficiently into cells. NAD+ cannot easily enter the body because of the barrier presented by the cell membrane. The membrane has a waterless space which  prevents ions, polar molecules, and large molecules from entering without the use of transporters. It was once thought that NMN must be altered before entering cells but new evidence suggests that it can enter cells directly via an NMN-specific transporter in the cellular membrane.

Furthermore, injections of NMN result in increased NAD+ in many regions in the body including the pancreas, fat tissue, the heart, skeletal muscle, kidneys, testes, eyes, and blood vessels. Oral administration of NMN in mice increases NAD+ in the liver within 15 minutes.